mcq in the general pharmacology.
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mcq in the general pharmacology.
Drug delivery method LEAST suitable for long term (days to weeks) slow release.
? pellet implant under the skin (subcutaneous)
:-) time release capsule
? i.m. injection of a drug-oil suspension
X transdermal patch
X none of the above
Most drug have molecular weights between:
? 10 - 100
? 100 and 1000
? 7 - about 60000
? above 60000
? none of the above
Bond type that is seen in some drug-receptor interactions and tends to very strong, often nearly irreversible:
? hydrophobic
? electrostatic
? covalent
? A & C
? B & C
Dramatic decrease in systemic availability of a drug following oral administration is most likely due to:
? extreme drug instability at stomach pH
? hepatic "first-pass" effect
? drug metabolized by gut flora
? tablet does not dissolve
? patient non-complance
Term having to do with drug actions on the body:
? pharmacokinetics
? pharmacodynamics
? pharmacogenetics
? placebo
? all of the above
Weak organic acid, pKa 6.5. Percent ionization at pH 7.5
? 1%
? 10%
? 50%
? 90%
? 99%
Example(s) of covalent drug-receptor interactions:
? activated phenoxybenzamine-receptor
? anti-cancer DNA alkylating drugs, like cyclophosphamide (Cytoxan)
? norepinephrine
? A & B
? A, B & C
Mechanism(s) of drug permeation:
? lipid diffusion
? aqueous diffusion
? use of carrier molecules
? endocytosis and exocytosis
? all of the above
Pharmacological antagonists:
? cause receptor down regulation
? prevent binding of other molecules to the receptor by their binding to the receptor
? atropine (blocks ACh action on the heart
? A & B
? B & C
Most common mechanism of drug permeation:
? endocytosis
? carrier-mediated transport
? active-transport
? passive diffusion
? none of the above
Drug-transport system described as "energy requiring":
? glomerular filtration
? facilitated diffusion
? active transport
? B & C
? A, B & C
Most important factor influencing drug absorption rate following intramuscular injection:
? needle diameter
? rate of administration
? injection site blood flow
? injection volume
Faster drug absorption:
? lung
? stomach
Drug with this ionization property most likely to diffuse from intestine (pH 8.4) to blood (pH 7.4)
? weak acid (pKa 7.4)
? weak base (pKa 8.4)
? weak acid (pKa 8.4)
? weak base (pKa 6.4)
? weak acid (pKa 6.4)
Increasing ionization at pH ABOVE pKa:
? weak acid
? weak base
General term having to do with actions of the body on the drug:
? pharmacodynamics
? pharmacogenetics
? pharmacokinetics
? absorption
? none of the above
? pellet implant under the skin (subcutaneous)
:-) time release capsule
? i.m. injection of a drug-oil suspension
X transdermal patch
X none of the above
Most drug have molecular weights between:
? 10 - 100
? 100 and 1000
? 7 - about 60000
? above 60000
? none of the above
Bond type that is seen in some drug-receptor interactions and tends to very strong, often nearly irreversible:
? hydrophobic
? electrostatic
? covalent
? A & C
? B & C
Dramatic decrease in systemic availability of a drug following oral administration is most likely due to:
? extreme drug instability at stomach pH
? hepatic "first-pass" effect
? drug metabolized by gut flora
? tablet does not dissolve
? patient non-complance
Term having to do with drug actions on the body:
? pharmacokinetics
? pharmacodynamics
? pharmacogenetics
? placebo
? all of the above
Weak organic acid, pKa 6.5. Percent ionization at pH 7.5
? 1%
? 10%
? 50%
? 90%
? 99%
Example(s) of covalent drug-receptor interactions:
? activated phenoxybenzamine-receptor
? anti-cancer DNA alkylating drugs, like cyclophosphamide (Cytoxan)
? norepinephrine
? A & B
? A, B & C
Mechanism(s) of drug permeation:
? lipid diffusion
? aqueous diffusion
? use of carrier molecules
? endocytosis and exocytosis
? all of the above
Pharmacological antagonists:
? cause receptor down regulation
? prevent binding of other molecules to the receptor by their binding to the receptor
? atropine (blocks ACh action on the heart
? A & B
? B & C
Most common mechanism of drug permeation:
? endocytosis
? carrier-mediated transport
? active-transport
? passive diffusion
? none of the above
Drug-transport system described as "energy requiring":
? glomerular filtration
? facilitated diffusion
? active transport
? B & C
? A, B & C
Most important factor influencing drug absorption rate following intramuscular injection:
? needle diameter
? rate of administration
? injection site blood flow
? injection volume
Faster drug absorption:
? lung
? stomach
Drug with this ionization property most likely to diffuse from intestine (pH 8.4) to blood (pH 7.4)
? weak acid (pKa 7.4)
? weak base (pKa 8.4)
? weak acid (pKa 8.4)
? weak base (pKa 6.4)
? weak acid (pKa 6.4)
Increasing ionization at pH ABOVE pKa:
? weak acid
? weak base
General term having to do with actions of the body on the drug:
? pharmacodynamics
? pharmacogenetics
? pharmacokinetics
? absorption
? none of the above
رد: mcq in the general pharmacology.
thax alot Dude thst's so kind of u
أميرة ليبيا- عضو نيو ليبيا
-
عدد الرسائل : 559
العمر : 37
العمل/الترفيه : شركة الواحه
بنغازي
تقييم الاعضاء لك : 7
تاريخ التسجيل : 26/05/2009
صفحة 1 من اصل 1
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